Abstract : In orthodontics attaining absolute anchorage is one of the greater tasks for successful outcome of the treatment. The purpose of this study was to investigate the inhibitory effect of locally administered bisphosphonate – pamidronate on orthodontic tooth movement (OTM) in Newzealand albino male rabbits which could support the ‘Pharmacological Anchorage System’ i.e. preventing unwanted tooth movement to accomplish orthodontic anchorage by local administration of certain drugs.The present experimental study was carried out for ‘21’ days on ‘20’ rabbits [ 10- Control and 10- Experimental ] with 3.75 to 4 kg wt. On the 1st day the animals received orthodontic appliance between 1st molar and incisors of the mandible. On day 1, 7 and 14, control animals received normal saline and experimental animals received Bp- pamidronate 1.5mg/0.5ml locally. After 21days the animals were sacrificed and the mandibles were dissected. The 1st molars with intact mesial aspect of alveolar bone were sectioned and processed for histological study and performed osteoclastic count under light microscope. Student ‘t’ test was used to compare the two groups and found significant (P0.001) difference="" between="" two="" groups.="" The="" present="" study="" concluded="" that="" locally="" administered="" Bp="" ( pamidronate="") had="" shown="" decreased="" osteoclastic="" count="" and="" reduced="" tooth="" movement.=""